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cenobamate will lessen the level or impact of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Maximize dose of CYP3A4 substrate, as necessary, when coadministered with cenobamate.avapritinib and fentanyl transdermal both raise sedation. Keep away from or Use Alternate Drug. Limit